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Synlett 1997; 1997(2): 187-188
DOI: 10.1055/s-1997-745
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Synthesis of 1α, 25-Dihydroxyvitamin D3 A-Ring Synthon by Pd-Catalyzed Cyclization

Hajime Yokoyama1 , Kazuhisa Miyamoto1 , Yoshiro Hirai1 , Takashi Takahashi2
  • 1Department of Chemistry, Toyama University, Toyama 930, Japan
  • 2Department of Chemical Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152, Japan
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Publication Date:
31 December 2000 (online)

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A short and efficient synthesis of 1α, 25-dihydroxyvitamin D3 A-ring synthon starting from diketene, acrolein and ethyl malonate by using palladium-catalyzed cyclization of the (Z)-enol triflate is described.

Heck reaction - Vitamin D3 - cyclization