PDF herunterladen
Synlett 1997; 1997(1): 115-116
DOI: 10.1055/s-1997-719
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Facile Synthesis of α-Amino Nitriles Using Lanthanide Triflate as a Lewis Acid Catalyst

Shû Kobayashi* , Haruro Ishitani, Masaharu Ueno
  • *Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT), Kagurazaka, Shinjuku-ku, Tokyo 162, Fax 3-3260-4726
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. März 2004 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

In the presence of a catalytic amount of lanthanide triflate, imines react with cyanotrimethylsilane (TMSCN) to afford α-amino nitriles in excellent yields. Although some imines are difficult to prepare and purify, three-component reactions of aldehydes, amines, and TMSCN proceeded smoothly. Effects of water in these reactions and application to asymmetric synthesis are also discussed.

Strecker reaction - lanthanide triflate - α-amino nitrile - cyanation - three-component reaction