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Synlett 1997; 1997(SI): 460
DOI: 10.1055/s-1997-6127
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The Hydrogenation and Deuteration of Estrone

Kristiina Wähälä* , Paula Kiuru, Seppo Kaltia, Jorma Koskimies, Tapio Hase
  • *University of Helsinki, Department of Chemistry, PO Box 55, 00014 UNIVERSITY, Finland, Email: Kristiina.Wahala@Helsinki.Fi
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Publication Date:
31 December 2000 (online)

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Hydrogenation (H2/PdC) of estrone (1) gives estrane-3,17-dione (2), the 5α, 10α A/B ring fusion stereochemistry being established by NMR. Reduction of estrone using D2/PdC gives 1α,2α,4α,5α,6,6,9α,10α-d8-estrane-3,17-dione (3).

deuteration - estrone - d8-5α,10α-estrane-3,17-dione

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