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Synlett 1997; 1997(6): 650-652
DOI: 10.1055/s-1997-3259
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Design and Synthesis of b-Series Ganglioside Mimetics

Tsuyoshi Miura1 , Mitsuaki Aonuma1 , Tetsuya Kajimoto1 , Yoshiteru Ida1 , Mitsuo Kawase2 , Yuji Kawase, Yasuko Yoshida
  • 1School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan
  • 2NGK Insulators Ltd., 1 Maegata-cho, Handa, Aichi 475, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Artificial glycolipids composed from phosphatidyl-ethanolamine and one or two sets of sialylα(2-8)sialoside were designed and prepared as mimetics of b-series gangliosides, GD3 and GQlb, which have respectively cholinergic differentiation potency in murine neuroblastoma cells and neutritogenic effect in human neuroblastoma cell line.

GQ1b - GD3 - ganglioside - mimic

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