Download PDF
Synlett 1997; 1997(9): 1111-1113
DOI: 10.1055/s-1997-1550
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Unified Procedure for Diastereo- and Enantiocontrolled Construction of Compactin Lactone and Calcitriol Enyne

Mitsuru Oizumi, Michiyasu Takahashi, Kunio Ogasawara*
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81-22-217-6845; email konol@mail.cc.tohoku.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A unified diastereo- and enantiocontrolled entry into compactin lactone, an essential structural moiety for the biological activity of compactin, and calcitriol enyne, an A-ring precursor of calcitriol, has been developed by use of the same stereocontrol procedure starting from enantiomeric epichlorohydrins.

compactin lactone - calcitriol enyne - optically active epichlorohydrin - optically active O-benzylglycidol - diastereo- and enantiocontrolled synthesis