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Synthesis 1997; 1997(11): 1281-1284
DOI: 10.1055/s-1997-1344
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Bis(hydroxymethylation) of the Active Methylene Group of 1,3-Dicarbonyl and Related Compounds

Andrei Guzaev* , Harri Lönnberg
  • *Department of Chemistry, University of Turku, FIN-20014 Turku, Finland, Fax +358(2)3336770; E-mail: harlon@utu.fi
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Publication History

Publication Date:
31 December 2000 (online)

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Treatment of dialkyl and di(aralkyl) malonates, alkyl cyano- and acetoacetates, and 1,3-diketones with formaldehyde in the presence of tertiary amines gives their 2,2-bis(hydroxymethyl) derivatives in 59 to 96% yield.

Specified 1,3-dicarbonyl compounds were bis-hydroxy-methylated with formaldehyde (10 examples)