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Synthesis 1997; 1997(10): 1189-1194
DOI: 10.1055/s-1997-1335
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A Practical Synthesis of Ureas from Phenyl Carbamates

Bounkham Thavonekham*
  • *Bio-Méga Research Division, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec H7S 2G5 Canada, Fax +1(514)6824189; E-mail: bthavonekham@bio-mega.boehringer-ingelheim.ca
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Publication History

Publication Date:
31 December 2000 (online)

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Using DMSO as solvent, a mild and efficient procedure for the synthesis of unsymmetrical N,N'-disubstituted ureas from phenyl carbamates is described. The carbamates are treated with a stoichiometric amount of amine at ambient temperature, generating the ureas in high yield and high purity. The reaction is mild, fast, and easily scaled up.

phenyl carbamates - unsymmetrical ureas - mild conditions - DMSO as solvent