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Synthesis 1997; 1997(4): 461-464
DOI: 10.1055/s-1997-1204
DOI: 10.1055/s-1997-1204
paper
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An Effective Synthesis of 2-Trifluoromethyl- or 2-(1,1-Difluoroalkyl)thiophenes
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synthesis/199704/lookinside/thumbnails/10.1055-s-1997-1204-1.jpg)
Various thiophenecarboxylates carrying a 2-trifluoromethyl, 2-(1,1-difluoroalkyl) or 2-polyfluoroalkyl group are synthesized conveniently from reaction of α-fluoroalkyl ketones 1, aldehydes 2 or ethyl α-fluoroalkylacetates 3 with methyl (or ethyl) 2-sulfanylacetates 4. A possible reaction pathway is suggested.
synthesis - fluoroalkylthiophenes - cyclocondensation reaction - α-fluoroalkyl carbonyl compounds - alkyl 2-sulfanylacetate