Synthesis 1997; 1997(4): 461-464
DOI: 10.1055/s-1997-1204
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Effective Synthesis of 2-Trifluoromethyl- or 2-(1,1-Difluoroalkyl)thiophenes

Hui-Ping Guan, Bing-Hao Luo, Chang-Ming Hu*
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenling Lu, Shanghai 200032, People’s Republic of China, Fax +86(21)64166128
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Various thiophenecarboxylates carrying a 2-trifluoromethyl, 2-(1,1-difluoroalkyl) or 2-polyfluoroalkyl group are synthesized conveniently from reaction of α-fluoroalkyl ketones 1, aldehydes 2 or ethyl α-fluoroalkylacetates 3 with methyl (or ethyl) 2-sulfanylacetates 4. A possible reaction pathway is suggested.