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Synthesis 1997; 1997(2): 202-206
DOI: 10.1055/s-1997-1154
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Synthesis of (E,E,E)-(1,2,3,4-13C4)-Geranylgeraniol

Knut Eis, Hans-Günther Schmalz*
  • *Institut für Organische Chemie, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623 Berlin, Germany, Fax +49(30)31421105; E-mail Schmalz@WAP0109.chem.tu-berlin.de
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Publication Date:
31 December 2000 (online)

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A synthesis of (E,E,E)-(1,2,3,4-13C4)-geranylgeraniol (2‘) (5 steps, ≥ 30% overall yield) is described starting from farnesol (3). The synthesis is based on the Sum/Weiler protocol, which was found to be superior after investigating two different routes in the non-labelled series.

geranylgeraniol - chain elongation - 13C labelled compounds - (1,2,3,4-13C4)-ethyl acetoacetate - protein lipidation