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Synlett 1997; 1997(12): 1342-1344
DOI: 10.1055/s-1997-1056
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A Convergent Synthesis of the tris-Oxazole Ring System in Ulapualide A and Related Marine Metabolites

Shital K. Chattopadhyay, Gerald Pattenden*
  • *Department of Chemistry, Nottingham University, University Park, Nottingham NG7 2RD, England, Fax 0115 9513535; GP@nottingham.ac.uk
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Publication History

Publication Date:
31 December 2000 (online)

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A convergent synthesis of the fully functionalised tris-oxazole system 16, found in the ulapualide family of marine macrolides, involving elaboration of the substituted oxazoles 13 and 8, followed by their coupling to the amide 14 and manipulation of the third oxazole ring via the oxazoline intermediate 15, is described.

tris-oxazoles - ulapualides

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