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Synlett 1997; 1997(12): 1414-1416
DOI: 10.1055/s-1997-1050
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Simple and Efficient Preparation of Ketones from Morpholine Amides

R. Martín, P. Romea1 , C. Tey, F. Urpí2 , J. Vilarrasa
  • 1Departament de Química Orgánica, Facultat de Química, Universitat de Barcelona, 08028 Barcelona, Catalonia (Spain), Fax: +34 3 3397878; E-mail: prg@gsaa1.qo.ub.es
  • 2Departament de Química Orgánica, Facultat de Química, Universitat de Barcelona, 08028 Barcelona, Catalonia (Spain), Fax: +34 3 3397878; E-mail: fut@gsaa1.qo.ub.es
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Publikationsdatum:
31. Dezember 2000 (online)

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Morpholine-derived amides react with RMgX to give the corresponding ketones in good yield. The mild conditions required and low cost of starting materials make this method very appealing for large scale preparations.

acylation - morpholine amides - ketones