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Synlett 1997; 1997(11): 1297-1299
DOI: 10.1055/s-1997-1034
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Enzyme-mediated optical resolution of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing terminal allenyl group

Tadayoshi Konegawa, Yoshikazu Ohtsuka, Hajíme Ikeda, Takeshi Sugai* , Hiromichi Ohta
  • *Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama 223, Japan, Fax 81 45 563 5967; sugai@chem.keio.ac.jp
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Publication Date:
31 December 2000 (online)

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Both enantiomers (>95% e.e.) of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing a terminal allenyl group were prepared via the two-stage enzymatic kinetic resolution, i.e., a sequence of lipase-catalyzed acetylation (Pseudomonas cepacia) and hydrolysis (Candida antarctica).

Pseudomonas cepacia lipase - Candida antarctica lipase - kinetic resolution - allenyl alcohol - hydrolysis - transesterification

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