Download PDF
Synlett 1996; 1996(11): 1085-1086
DOI: 10.1055/s-1996-5696
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Enzyme-Catalyzed Enantioselective Hydrolysis of 6-Membered Cyclic Carbonates Using Water-Immiscible Co-Solvent System

Kazutsugu Matsumoto* , Megumi Shimojo, Hidehiko Kitajima, Minoru Hatanaka
  • *Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Fukui University, Bunkyo 3-9-1, Fukui-shi, Fukui 910, Japan, FAX 81 776 27 8747, E-mail: mkazu@acbio.fukui-u.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

 PDF Download  Permissions and Reprints All articles of this category

The reaction of a 6-membered cyclic carbonate, 4-(2-benzyloxyethyl)-1,3-dioxan-2-one (dl-1), with PPL in phosphate buffer containing 50% i-Pr2O at 0 °C proceeded with good enantioselectivity, and optically active 1-substituted-1,3-diol derivatives are obtained. This procedure is applicable to a substrate having a undecyl group to afford side chain precursors of lipid A.

Enzymatic Hydrolysis - Cyclic Carbonates - Optically Active Diols