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Synlett 1996; 1996(6): 571-572
DOI: 10.1055/s-1996-5470
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A Convenient Epoxidation of α,β-Unsaturated Ketones with Sodium Hypochlorite under Phase Transfer Conditions Catalysed by Hexaethylguanidinium Chloride (HEGCl)

Thierry Schlama, Lilian Alcaraz, Charle Mioskowski*
  • *Laboratoire de Chimie Bio-Organique, Unité associée au CNRS, Université Louis Pasteur, Faculté de pharmacie, 67401 Illkirch-Graffenstaden, Tel: (33) 88 67 68 63, Fax: (33) 88 67 88 91
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Publication History

Publication Date:
31 December 2000 (online)

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For the first time hexaethylguanidinium chloride (HEGCl) was used as an efficient phase transfer agent in the epoxidation of α,β-unsaturated ketones under biphasic conditions.

α,β-epoxycarbonyls - α’,α’-dichloro-α,β-epoxycyclohexanones - sodium hypochlorite - guanidinium salts - phase transfer epoxidation