Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1996; 1996(2): 163-164
DOI: 10.1055/s-1996-5365
DOI: 10.1055/s-1996-5365
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Enantiocontrolled Synthesis and Absolute Configuration of (+)-Crooksidine, An Indole Alkaloid from Haplophyton Crooksii Using Chiral Piperideinol Block
Further Information
Publication History
Publication Date:
31 December 2000 (online)
(+)-Crooksidine has been synthesized first time starting from the optically pure (S)-3-piperidein-5-ol resolved by lipase-mediated kinetic transesterification. The key synthetic intermediate has also furnished another indole alkaloid (+)-(R)-decarbomethoxy-15,20:16,17-tetrahydrosecodine, occurred in the same plant, which has concluded the absolute configuration of (+)-crooksidine as R as well as that of the starting piperideinol as S.
lipase-mediated resolution - chiral piperideinol block - absolute configuration of crooksidine - indole alkaloid