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Synthesis 1996; 1996(4): 423-445
DOI: 10.1055/s-1996-4250
review
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Synthesis of Radiopharmaceuticals via Organotin Intermediates

Hasrat Ali, Johan E. van Lier*
  • *MRC Group in the Radiation Sciences, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Québec, J1H 5N4, Canada, Fax +1(819)5645442; E-mail jvanlier@courrier.usherb.ca
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Publikationsdatum:
31. Dezember 2000 (online)

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The basic concepts and uses of organotin intermediates in the rapidly growing domain of radiopharmaceutical chemistry are reviewed. Organotin intermediates can readily be prepared, and radiohalodestannylation is both efficient and site selective to give labeled products in good yields and high specific activities.

organotin intermediates - iododestannylation - radiohalogens - radiopharmaceuticals