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Synlett 1995; 1995(SI): 533-535
DOI: 10.1055/s-1995-5288
DOI: 10.1055/s-1995-5288
letter
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On the Protein Kinase C Pharmacophore: Synthesis and Biological Activity of 4-Hydroxylated Analogs of Ingenol
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synlett/1995SupI/lookinside/thumbnails/10.1055-s-1995-5288-1.jpg)
The synthesis and preliminary biological evaluation of the first C-4 hydroxylated analog of ingenol are described. The activity of 4 demonstrates that the C-4 hydroxyl group is not a critical component of the pharmacophore for protein kinase C binding and activation.
ingenol - protein kinase C - pharmacophore - structure-activity relationships