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Synlett 1995; 1995(SI): 575-577
DOI: 10.1055/s-1995-5268
DOI: 10.1055/s-1995-5268
letter
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A Convenient Synthesis of Versatile Side-chain Intermediates for Carbapenem Antibiotics
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synlett/1995SupI/lookinside/thumbnails/10.1055-s-1995-5268-1.jpg)
A useful synthesis of (2S, 4S)-4-(4-methoxybenzylthio)-1-substituted pyrrolidinecarboxylic acid is reported. At each step, practically all compounds were obtained in crystalline form by simple procedure without column chromatography. These compounds are versatile side-chain precursors to carbapenem antibiotics.
substituted pyrrolidinecarboxylic acid - N-methylation - side-chain precursors of carbapenem - β-lactam antibiotics