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Synlett 1995; 1995(SI): 510-512
DOI: 10.1055/s-1995-5263
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Design and Synthesis of D-Ribofuranoamidrazones as Inhibitors of Nucleoside Processing Enzymes

Markus Boutellier, Bruce Ganem* , Benjamin A. Horenstein, Vern L. Schramm
  • *Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA
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Publication Date:
31 December 2000 (online)

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The five-membered amidrazones 1-4, designed as stable mimics of the ribofuranosyl cation, are potent competitive inhibitors of nucleoside hydrolase from Crithidia fasciculata.

nucleoside hydrolase - transition structure - thionolactam addition