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Synlett 1995; 1995(10): 1077-1078
DOI: 10.1055/s-1995-5184
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Direct Synthesis of Chiral Acetals from Carbonyl Compounds and Chiral Diols: Sequential One-Pot Asymmetric Silylcyanation Reaction Catalyzed by Scandium(III) Triflate

Shin-ichi Fukuzawa* , Teruhisa Tsuchimoto, Tsutomu Hotaka, Tamejiro Hiyama
  • *Department of Applied Chemistry, Chuo University, Kasuga, Bunkyo-ku, Tokyo 112, Japan, Fax 81 3 3817 1895; E-mail fukuzawa@apchem.chem.chuo-u.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Chiral acetal formation followed by cyanation of carbonyl compounds was successfully carried out in one-pot using chiral diols, scandium (III) triflate and then trimethylsilyl cyanide.

Scandium(III) triflate - chiral acetal - asymmetric silylcyanation - cyanohydrin