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Synlett 1995; 1995(10): 1057-1058
DOI: 10.1055/s-1995-5177
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Asymmetric Catalysis of the Mukaiyama Aldol Reaction with Fluoral: A Highly Enantioselective Access to Fluorine-containing Aldols

Koichi Mikami* , Tsuyoshi Takasaki, Satoru Matsukawa, Masamichi Maruta
  • *Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan
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Publication Date:
31 December 2000 (online)

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The chiral titanium complex-catalyzed Mukaiyama aldol reaction with fluoral is shown to serve as an efficient route to the enantioselective synthesis of CF3-substituted aldol of biological and synthetic importance.

aldol reaction - asymmetric catalyst - titanium complex - fluoral