Synlett 1995; 1995(9): 965-966
DOI: 10.1055/s-1995-5136
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Unusual anti-Selective Reduction of α-Methyl β-Alkylketo Esters by Organotin Hydride-Titanium Tetrachloride

Tsuneo Sato, Mitsuhisa Nishio, Junzo Otera*
  • *Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama 700, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

The highly stereoselective reduction of α-methyl β-keto esters is achieved by use of organotin hydride in the presence of titanium tetrachloride to give the anti β-hydroxy esters.