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Synlett 1995; 1995(9): 931-932
DOI: 10.1055/s-1995-5117
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An Efficient Approach to the Synthesis of a Key Precursor of Mammalian Squalene Epoxidase Inhibitors Using a New Method for Transforming Aryl Bromides to Phenols

Jean-Pierre Gotteland* , Serge Halazy
  • *Medicinal Chemistry IV, Centre de Recherche P. Fabre, 17 Avenue Jean Moulin, 81106, Castres Cedex, France, Fax: (33).63.71.42.99
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Publication Date:
31 December 2000 (online)

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Phenol 4, a key precursor of mammalian squalene epoxidase inhibitors, is obtained through a straightforward three steps synthesis using a new aryl bromide to phenol transformation.

Squalene epoxidase - inhibitor - oxidation - aryl boronate - phenol