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Synlett 1995; 1995(8): 871-872
DOI: 10.1055/s-1995-5102
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Efficient Synthesis of Naturally Occurring Ligustilide

Yoshimitsu Ogawa, Masao Maruno, Takeshi Wakamatsu*
  • *Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-11, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Synthesis of naturally occurring ligustilide (1) was accomplished by the cyclization of alkynoic acid (9), which was prepared from acetal (3) in several steps, catalyzed by silver iodide or silver in mild reaction condition as key step.

ligustilide - cyclization - silver catalyst - alkynoic acid