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Synlett 1995; 1995(7): 700-702
DOI: 10.1055/s-1995-5059
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An Asymmetric Synthesis of N-Protected β-Amino Aldehydes and β-Amino Ketones

Stephen G. Davies* , Tom D. McCarthy
  • *The Dyson Perrins Laboratory, South Parks Road, OXFORD, OX1 3QY, UK
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Publication History

Publication Date:
31 December 2000 (online)

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The stereoselective addition of lithium (S)-(α-methylbenzyl)benzylamide to αβ-unsaturated Weinreb amides gives the conjugate addition products with high stereoselectivities (99:1) which can be transformed into protected homochiral β-amino aldehydes and ketones.

β-amino aldehydes - β-amino ketones - stereoselective - homochiral - conjugate addition