Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1995; 1995(6): 619-621
DOI: 10.1055/s-1995-5026
DOI: 10.1055/s-1995-5026
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Homochiral Proline N-Oxides as Conformational Constraints in Peptide Like Molecules
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199506/lookinside/thumbnails/10.1055-s-1995-5026-1.jpg)
The preparation of a number of N-alkylated proline derivatives which bear hydrogen bond donors in both the carboxyamide side chain and the N-substituent is described. Oxidation with m-CPBA gives homochiral amine oxides where the amine oxide configuration is determined by the proline side chain NH group. The amine oxides are stabilized by the presence of two intramolecular hydrogen bonds. These initial results have been extended to the preparation of homochiral tripeptide like molecules.
Homochiral Amine Oxides - Hydrogen Bonding - Peptide