Synlett 1995; 1995(2): 142-144
DOI: 10.1055/s-1995-4901
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The Enantioselective Synthesis of Neopentylamine Derivatives

Neil Moss* , Jean Gauthier, Jean-Marie Ferland
  • *Bio-Méga/Boehringer Ingelheim Research Inc., 2100 Cunard, Laval, Quebec, Canada, H7S 2G5
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Enantiomerically pure neopentylamine derivatives 1 can be readily prepared from ketones 2 by a four step sequence involving imine formation with R-α-methylbenzylamine followed by a highly diastereoselective reduction with NaBH4.