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Synlett 1995; 1995(2): 205-206
DOI: 10.1055/s-1995-4897
DOI: 10.1055/s-1995-4897
letter
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Preparation of N-9-Fluorenylmethyloxycarbonyl-Asparagine-Pentafluorophenyl Ester from the Free Acid
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199502/lookinside/thumbnails/10.1055-s-1995-4897-1.jpg)
We report a new method for synthesising Fmoc-asparagine pentafluorophenyl ester from the free acid which is suitable for use directly in peptide assemblies. The coupling reagent 1-(3-dimethylaminopropyl)-3-ethylcarbodi-imide hydrochloride (EDC) is found to be highly effective for activating non-sidechain protected asparagine and it facilitates an efficient water-based work-up. Yields of product are typically in the range of 65-75%.
Solid phase peptide synthesis - Fmoc-Asn-OPfp - Isotope-edited NMR spectroscopy