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Synthesis 1995; 1995(12): 1447-1464
DOI: 10.1055/s-1995-4143
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Annonaceous Acetogenins - Synthetic Approaches Towards a Novel Class of Natural Products

R. Hoppe, H.-D. Scharf*
  • *Institut für Organische Chemie der RWTH Aachen, Prof. Pirlet Str. 1, D-52056 Aachen, Germany, Fax +49(241)8888127
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Publikationsdatum:
31. Dezember 2000 (online)

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Constituents of the plant family Annonaceae, called Annonaceous acetogenins, have a broad field of biological activity ranging from insecticidal and fungicidal to cancerostatic effects. Since the first disclosure of a member of this class of natural products by Cole and co-workers in 1982, more than 90 members of this class of compounds have been isolated to date. The goal of the present review is to summarize the knowledge concerning Annonaceous acetogenins with the focal point being on the synthetic work.

Annonaceous acetogenins - annona - tetrahydrofuran - butyrolactone - butenolide - natural product