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Synthesis 1995; 1995(8): 1033-1037
DOI: 10.1055/s-1995-4036
DOI: 10.1055/s-1995-4036
paper
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1,8-Disubstituted Naphthalenes by Directed Metalation and Subsequent Lithium-Manganese Exchange, Including Copper Catalysis
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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Directed lithiation of 1-dimethylamino- and 1-methoxynaphthalene, followed by Li-Mn exchange and reaction with electrophiles, provides regioselective syntheses of previously unknown racemic thioamides 2, 11 and 12, and ketones 5-8.
Lithiation of 1-substituted naphthalenes, followed by Li-Mn exchange, served for synthesis of title compounds.