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Synthesis 1995; 1995(4): 373-375
DOI: 10.1055/s-1995-3929
short paper
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Direct Synthesis of Thiols from Halides and Epoxides Using Hydrosulfide Exchange Resin in Methanol

Jaesung Choi, Nung Min Yoon*
  • *Department of Chemistry, Sogang University, Seoul 121-742, South Korea
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Publication Date:
31 December 2000 (online)

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Various thiols are prepared directly from the corresponding alkyl halides and epoxides using hydrosulfide exchange resin in methanol in the presence of equimolar amounts of triethylammonium chloride at room temperature. The reaction not only proceeds with unique chemoselectivity, but also gives better yields of thiols than most commonly used indirect methods and has an additional advantage of a simple workup.

Synthesis of various thiols from halides and epoxides is reported.