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Synthesis 1995; 1995(4): 382-384
DOI: 10.1055/s-1995-3916
short paper
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Mild and Efficient Synthesis of N-Unsubstituted 1,4-Dihydropyridines

Rodolfo Lavilla* , Teresa Gotsens, Marta Guerrero, Joan Bosch1
  • *Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona E-08028, Spain
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Publikationsdatum:
31. Dezember 2000 (online)

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The synthesis of the title compounds through a two-step procedure consisting of the addition of an indole to an N-acylpyridinium salt followed by mild hydrolysis of the resulting N-acyl-1,4-dihydropyridines is reported.

N-H dihydropyridine - indole - N-acylpyridinium salt - oxidation - iminium ion