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Synthesis 1994; 1994(2): 152-154
DOI: 10.1055/s-1994-25425
short paper
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Synthesis of Some New Spiro(pyran-4,2′-benzoxazole) Derivatives

A. K. El-Shafei* , A. M. M. El-Saghier, E. A. Ahmed
  • *Chemistry Department, Faculty of Science, Sohag, Egypt
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Publication Date:
17 September 2002 (online)

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Ketene S,S-acetal 2 reacts with 2-aminophenol to afford 2-(1-acetyl-2-oxopropylidene)benzoxazole (3) which was allowed to react with a variety of active methylenes having an α-cyano or α-keto group to give spiro[pyran-4,2′-benzoxazole] derivatives 5-12. Compound 3 also reacts with bromomalononitrile to afford spiro[3,3-diacetyl-2,2-dicyanocyclopropane-1,2′-benzoxazole] 13 through a nucleophilic addition and cyclization.