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Synthesis 1994; 1994(1): 73-76
DOI: 10.1055/s-1994-25408
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Synthesis of a 6H-Pyrazolo[4,5,1-de]acridin-6-one Derivative: A Useful Intermediate of Antitumour Agents

Toru Sugaya* , Yukiteru Mimura, Nobuyuki Kato, Masanori Ikuta, Takashi Mimura, Masaji Kasai, Shinji Tomioka
  • *Sakai Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., 1-1-53 Takasucho, Sakai 590, Japan
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Publication Date:
17 September 2002 (online)

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A 6H-pyrazolo[4,5,1-de]acridin-6-one derivative, a useful intermediate of antitumor agents, was prepared by a facile synthetic route from 2-bromobenzoic acid and 6-nitroindazole involving a halogenocopper(I)-catalyzed Ullmann coupling reaction and Friedel-Crafts cyclization.