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Synthesis 1994; 1994(1): 31-33
DOI: 10.1055/s-1994-25398
short paper
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An Improved Procedure for the Preparation of the Garner Aldehyde and Its Use for the Synthesis of N-Protected 1-Halo-2-(R)-amino-3-butenes

Alexander Mckillop* , Richard J. K. Taylor, Robert J. Watson, Norman Lewis
  • *School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, England
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Publication Date:
17 September 2002 (online)

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An improved procedure for the preparation of 1,1-dimethylethyl 2,2-dimethyl-4-(S)-formyloxazolidine-3-carboxylate (Garner aldehyde) is described which avoids the need for methyl iodide and benzene. Elaboration of this aldehyde into the novel chiral building blocks mentioned in the title is also described.