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Synlett 1994; 1994(10): 823-824
DOI: 10.1055/s-1994-23017
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Steric and Electronic Effects in Arene Formylations involving Pyrophosphoryl Chloride

Sunil V. Pansare* , R. Gnana Ravi
  • *Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
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Publication Date:
22 March 2002 (online)

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The regiochemistry of formylation of several activated naphthalenes and benzenes with pyrophosphoryl chloride and N, N-disubstituted formamides is governed by steric demands of the formylating species and the substrate, but electronic factors may dominate in some cases. Increasing the size of the formamide in the formylating reagent is beneficial for controlling regioselectivity.