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Synlett 1994; 1994(9): 751-753
DOI: 10.1055/s-1994-22997
DOI: 10.1055/s-1994-22997
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Synthesis of N-Alkyl α-Trifluoromethyl α-Amino Acids and Incorporation into Peptides
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Publikationsverlauf
Publikationsdatum:
18. September 2002 (online)
4-Trifluoromethyl-1,3-oxazolidine-2,5-diones are alkylated on treatment with sodium hydride/alkyl iodide to yield N-alkyl trifluoromethyl Leuchs anhydrides. Dipeptide esters with N-alkyl α-trifluoromethyl α-amino acids in the N-terminal position are obtained on reaction of N-alkyl TFM Leuchs anhydrides with amino acid esters.