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Synlett 1994; 1994(7): 545-546
DOI: 10.1055/s-1994-22923
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Scandium Trifluoromethanesulfonate. A Novel Catalyst for Friedel-Crafts Acylation

Atsushi Kawada* , Shuichi Mitamura, Shū Kobayashi
  • *Nippon Steel Corporation, Advanced Materials & Technology Research Laboratories, 1618 Ida, Nakahara-ku, Kawasaki 211, Japan
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Publication History

Publication Date:
18 September 2002 (online)

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Scandium trifluoromethanesulfonate (Sc(OTf)3) was found to be a novel catalyst for Friedel-Crafts acylation. The reactions of substituted benzenes with acid chlorides or anhydrides proceeded smoothly even in the presence of a catalytic amount of Sc(OTf)3. While Sc(OTf)3 is a reusable catalyst similar to lanthanide trifluoromethanesulfonates, its catalytic activity is much higher than that of lanthanide analogs.