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Synlett 1994; 1994(7): 482-484
DOI: 10.1055/s-1994-22896
DOI: 10.1055/s-1994-22896
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics1
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Publikationsverlauf
Publikationsdatum:
18. September 2002 (online)
![](https://www.thieme-connect.de/media/synlett/199407/lookinside/thumbnails/10.1055-s-1994-22896-1.jpg)
Intramolecular addition of silylacetylene to the aldehyde was effected to cyclize 10-membered enediyne compound with cesium fluoride in the presence of 18-crown-6 in THF. A small amount of acetonitrile improved the yield and reproducibility. The product was transformed to the enone which is a new simple. model compound of esperamicin/calicheamicin aglycon.