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Synlett 1994; 1994(6): 433-434
DOI: 10.1055/s-1994-22878
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A Short Synthesis of (±)-Clavizepine

R. Vázquez* , M. C. de la Fuente, L. Castedo, D. Domínguez
  • *Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago y Sección de Alcaloides del C.S.I.C. 15706 Santiago de Compostela, Spain
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Publication History

Publication Date:
18 September 2002 (online)

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A new synthesis of (±)-clavizepine is described which is based on the anionic cyclization of the bromo ester 5 to give the xanthene 9-carboxylate 6, followed by construction of the azepine ring by intramolecular aromatic substitution of the amido acetal 9.