Download PDF
Synlett 1994; 1994(6): 417-419
DOI: 10.1055/s-1994-22871
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Synthesis of Salinomycin. Part 2. Synthesis of the Dispiroacetal Core Unit via Oxidative Rearrangement of an Acyl Furan

Richard C. D. Brown* , Philip J. Kocieński
  • *Department of Chemistry, The University, Southampton, SO9 5NH, U.K.
Further Information

Publication History

Publication Date:
18 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A synthesis of the polyether antibiotic Salinomycin is completed by the union of the C11-C20 furan fragment 2, the C21-C30 lactone fragment 3 , and the C1-C9 tetrahydropyran fragment 14. A key step in the sequence is the oxidative rearrangement of a 2-acyl furan to the 1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene core unit.