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Synlett 1994; 1994(3): 162-164
DOI: 10.1055/s-1994-22776
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Synthesis of Peraceto-β-D-Glycosyl Fluorides Using Zinc Fluoride

K. D. Goggin* , J. F. Lambert, S. W. Walinsky
  • *Central Research Division, Pfizer Inc, Eastern Point Road, Groton, Connecticut 06340
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Publication Date:
22 March 2002 (online)

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A new method to prepare O-protected β-D-glycosyl fluorides by reacting α-D-glycosyl bromides with ZnF2 or ZnF2/2,2′-bipyridine combinations in acetonitrile is described. The addition of 2,2′-bipyridine to the halide exchange reaction increases product yields, but 2,2′-bipyridine does not appreciably accelerate the reaction rate nor increase the solubility of ZnF2 in CH3CN.