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Synlett 1994; 1994(1): 81-83
DOI: 10.1055/s-1994-22747
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A Reductive Amination/Lactamization Procedure Using Borohydride Reagents

Ahmed F. Abdel-Magid* , Bruce D. Harris, Cynthia A. Maryanoff
  • *The R. W. Johnson Pharmaceutical Research Institute, Chemical Development Department, Spring House, PA 19477, USA
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Publication Date:
22 March 2002 (online)

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We report a procedure for tandem reductive aminationlactamization of aldehydes or ketones with aminoesters or ketoesters with primary amines under mild conditions (NaBH(OAc)3/1,2-dichloroethane or NaBH4/ MeOH).