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Synlett 1994; 1994(1): 40-43
DOI: 10.1055/s-1994-22731
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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 2. Efficient Synthesis of C16-C26 Fragments via Construction of the D Ring by a Highly Stereocontrolled Iodoetherification

K. Horita* , M. Nagasawa, S. Hachiya, O. Yonemitsu
  • *Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan
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Publication Date:
22 March 2002 (online)

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A stereoselective synthesis of C16-C26 fragments of halichondrin B starting from D-malic acid and methyl (2S)-3-hydroxy-2-methylpropionate using iodoetherification for an efficient construction of the D ring as the key step is described.