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Synthesis 1993; 1993(11): 1029-1056
DOI: 10.1055/s-1993-25991
review
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Asymmetrized 2-Methyl-1,3-propanediol and Its Equivalents: Preparation and Synthetic Applications

Luca Banfi* , Giuseppe Guanti
  • *Istituto di Chimica Organica dell'Università degli Studi di Genova, and C.N.R., Centro di Studio per la Chimica dei Composti Cicloalifatici ed Aromatici, corso Europa 26, I-16132, Genova, Italy
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Publication Date:
29 April 2002 (online)

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This review describes the methods of enantioselective preparation and the main synthetic elaborations of asymmetrized 2-methyl-1,3-propanediol 1 and of its synthetic equivalents. 1 Introduction 2 Preparation 3 Functional Group Manipulation of β-Hydroxy-α-methylpropionic Acid Derivatives 4 Elongation Through Nucleophilic Substitution 5 Elongation Through Electrophilic Substitution 6 Elongation Through Olefination 7 Elongation Through Nucleophilic Addition 8 Miscellaneous Elaborations