Synthesis 1993; 1993(10): 955-957
DOI: 10.1055/s-1993-25976
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Studies on Organophosphorus Compounds; LXXV: A Facile Synthesis of 1-(Hydroxyamino)alkyl(or aryl)phosphonic Acids

Chengye Yuan* , Shoujun Chen, Hui Zhou, Ludwig Maier
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
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Publication History

Publication Date:
29 April 2002 (online)

Reduction of dialkyl 1-(hydroxyimino)alkyl(aryl)phosphonate 1 with borane-pyridine complex proceeds smoothly to give dialkyl 1-(hydroxyamino) alkyl(or aryl)phosphonate 2 which is then easily converted into the corresponding hydroxyaminophosphonic acid 3 by acidic hydrolysis.