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Synthesis 1993; 1993(1): 158-164
DOI: 10.1055/s-1993-25822
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Stereoselective Synthesis of Acceptor Stabilized Prostacyclins

F. Balkenhohl* , I. Brüning, E. Winterfeldt
  • *BASF Aktiengesellschaft, D-6700 Ludwigshafen/Rhein, Germany
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Publikationsdatum:
17. September 2002 (online)

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The preparation of acceptor substituted, stabilized prostacyclins is described. In this process use is made of a bulky ester group which additionally lends itself to directing the stereoselectivity of a deconjugation step for the introduction of the exocyclic double bond.