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Synthesis 1993; 1993(1): 51-53
DOI: 10.1055/s-1993-25790
short paper
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A General Oxindole Synthesis

George J. Quallich* , P. M. Morrissey
  • *Pfizer Central Research, Process Research and Development, Groton, Connecticut 06340, USA
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Publication Date:
17 September 2002 (online)

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A general synthesis of indol-2(3H)-ones (oxindoles), was developed based on the addition of dimethyl malonate to commercially available halonitrobenzenes. The advantage of this route over many other oxindole syntheses was the regiochemical control of the substitution pattern on the aromatic ring.

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