Download PDF
Synlett 1993; 1993(10): 759-760
DOI: 10.1055/s-1993-22599
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Copper Mediated Lithium Aluminum Hydride Reduction of Substituted Allylic Epoxides

J. F. Genus* , D. D. Peters, T. A. Bryson
  • *Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
Further Information

Publication History

Publication Date:
19 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Copper-mediated lithium aluminum hydride reduction of 1-oxaspiro[2.5]oct-4-enes has been observed to primarily yield 1,4-products, although 1,2-products and general decomposition are encountered. Olefin substitution (α and β) affects the yield and selectivity. Alternate hydride coordination sites redirect reductive opening of these allylic epoxides.